The mostly observed unwanted effects of pramipexole had been somnolence and edema. The most observed unwanted effects of levodopa were dyskinesias and wearing off commonly. Levodopa and pramipexole both seem to be reasonable options as initial dopaminergic therapy for PD, but are associated with different profiles of efficacy and adverse effects, stated Ira Shoulson, MD, professor of neurology, University of Rochester and principal investigator of the scholarly study. However, further study is required to assess the longer-term outcomes and cost-effectiveness of the treatments. The PSG of these cells produces a decrease in a vital chemical substance called dopamine, which in turn causes symptoms that can include shaking of hands, slowing of movement, loss and stiffness of stability.This article is republished with kind authorization from our friends at The Kaiser Family Foundation. You can view the complete Kaiser Daily Health Plan Statement, search the archives, or join email delivery of in-depth coverage of wellness policy developments, debates and discussions. The Kaiser Daily Health Policy Report is released for Kaisernetwork.org, a free of charge service of The Henry J. Kaiser Family Foundation. Copyright 2009 Advisory Plank Kaiser and Company Family Foundation. All rights reserved.. Can pregnant women drink in moderation? Five fresh studies out of Denmark claim that pregnant women who beverage low to moderate levels of alcohol during early pregnancy may not risk neurological and psychological harm to their child.